blast crisis การใช้

• It is highly expressed in blast crisis transition of chronic myeloid leukemia.
• "When I went into blast crisis, it was a whole new game, " he said.
• Gleevec was highly effective in preventing blast crisis, the most lethal form of the disease.
• Nearly all patients with CML in blast crisis or Ph + ALL relapsed within 6 months.
• Moreover, it inhibits DNA repair, causing genomic instability and potentially causing the feared blast crisis in CML.
• The end stage of the disease, known as blast crisis, can be fatal within several months, researchers said.
• The FDA however has only approved it for late-stage and blast crisis CML, as well as when interferon fails.
• The accelerated phase is significant because it signals that the disease is progressing and transformation to blast crisis is imminent.
• And only six Gleevec patients developed blast crisis CML, the lethal final stage of the disease, compared to 26 interferon patients.
• All but one with lymphoid blast crisis or acute lymphocytic leukemia have relapsed, but doctors are encouraged by the temporary responses.
• After his leukemia accelerated and other drugs no longer worked, Barnes moved into the most advanced blast crisis stage within a month.
• Of the 20 with lymphoid blast crisis or acute lymphocytic leukemia, 70 percent had a response, including four with complete responses, the researchers said.
• Seven patients with myeloid blast crisis continue to receive treatment and remain in remission from 101 to 349 days after beginning treatment, they said.
• Responses occurred in 55 percent of those with myeloid blast crisis, with four of those patients having their white blood cell counts returned to normal.
• Researchers also studied the effect of Glivec on patients in blast crisis-- 38 had myeloid blast crisis and 20 had acute lymphocytic leukemia or lymphoid blast crisis.
• Researchers also studied the effect of Glivec on patients in blast crisis-- 38 had myeloid blast crisis and 20 had acute lymphocytic leukemia or lymphoid blast crisis.
• Researchers also studied the effect of Glivec on patients in blast crisis-- 38 had myeloid blast crisis and 20 had acute lymphocytic leukemia or lymphoid blast crisis.
• Hematologic diseases in which it is positive include ALL, angioimmunoblastic T cell lymphoma, Burkitt lymphoma, chronic myelogenous leukemia in blast crisis ( 90 % ), diffuse large B-cell lymphoma ( variable ), follicular center cells ( 70 % ), hairy cell leukemia ( 10 % ), and myeloma ( some ).